学術論文

2024年

• Suzuki T, Joho D, Kakeyama M. Purposive decision-making task in mice using touchscreen operant apparatus. Neurosci Res. 2024;200:34-40. doi:10.1016/j.neures.2023.09.007.

2023年

• Joho D, Takahashi M, Suzuki T, Ikuta K, Matsumoto M, Kakeyama M. Probiotic treatment with Bifidobacterium animalis subsp. lactis LKM512 + arginine improves cognitive flexibility in middle-aged mice. Brain Commun. 2023;5(6):fcad311. doi:10.1093/braincomms/fcad311.
• Kimura E, Suzuki G, Uramaru N, Kakeyama M, Maekawa F. 2-Chloro-3,7,8-tribromodibenzofuran as a new environmental pollutant inducing atypical ultrasonic vocalization in infant mice. Toxicol Res (Camb). 2023;12(5):999-1004. doi:10.1093/toxres/tfad069.
• Ikuta K, Joho D, Kakeyama M, Matsumoto M. Bifidobacterium animalis subsp. lactis and arginine mixture intake improves cognitive flexibility in mice. Front Nutr. 2023;10:1164809. doi:10.3389/fnut.2023.1164809.

2022年

• Tamada H, Ikuta K, Makino Y, et al. Impact of Intestinal Microbiota on Cognitive Flexibility by a Novel Touch Screen Operant System Task in Mice. Front Neurosci. 2022;16:882339. doi:10.3389/fnins.2022.882339.
• Kimura E, Suzuki G, Uramaru N, Kakeyama M, Maekawa F. Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Appl Toxicol. 2022;42(2):305-317. doi:10.1002/jat.4220.

2021年

• Ueda S, Hosokawa M, Arikawa K, et al. Distinctive Regulation of Emotional Behaviors and Fear-Related Gene Expression Responses in Two Extended Amygdala Subnuclei With Similar Molecular Profiles. Front Mol Neurosci. 2021;14:741895. doi:10.3389/fnmol.2021.741895.
• Benner S, Aoki Y, Watanabe T, et al. Neurochemical evidence for differential effects of acute and repeated oxytocin administration. Mol Psychiatry. 2021;26(2):710-720. doi:10.1038/s41380-018-0249-4.

2020年

• Horigane SI, Ozawa Y, Zhang J, et al. A mouse model of Timothy syndrome exhibits altered social competitive dominance and inhibitory neuron development. FEBS Open Bio. 2020;10(8):1436-1446. doi:10.1002/2211-5463.12924.

2018年

• Endo N, Ujita W, Fujiwara M, et al. Multiple animal positioning system shows that socially-reared mice influence the social proximity of isolation-reared cagemates. Commun Biol. 2018;1:225. doi:10.1038/s42003-018-0213-5.

2017年

• Kimura E, Kubo KI, Endo T, et al. Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse. J Toxicol Sci. 2017;42:25-30. doi:10.2131/jts.42.25.
• Kimura E, Kubo KI, Endo T, et al. Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse. PLoS One. 2017;12(8):e0183497. doi:10.1371/journal.pone.0183497.
• Kubo KI, Deguchi K, Nagai T, et al. Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight. 2017;2(10):e88609. Published 2017 May 18. doi:10.1172/jci.insight.88609.

• Kimura E, Endo T, Yoshioka W, et al. In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain. Biochem Biophys Res Commun. 2016;476(2):108-113. doi:10.1016/j.bbrc.2016.05.048.
• Aung KH, Kyi-Tha-Thu C, Sano K, et al. Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice. Front Neurosci. 2016;10:137. doi:10.3389/fnins.2016.00137.

2015年

• Ishii K, Kubo K, Endo T, et al. Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits. J Neurosci. 2015;35(36):12432-12445. doi:10.1523/JNEUROSCI.3648-14.2015.
• Benner S, Kakeyama M, Endo T, Yoshioka W, Tohyama C. Application of NeuroTrace staining in the fresh frozen brain samples to laser microdissection combined with quantitative RT-PCR analysis. BMC Res Notes. 2015;8:252. doi:10.1186/s13104-015-1222-9.
• Takamura T, Nishitani S, Suegami T, Doi H, Kakeyama M, Shinohara K. Developmental changes in the neural responses to own and unfamiliar mother's smiling face throughout puberty. Front Neurosci. 2015;9:200. doi:10.3389/fnins.2015.00200.
• Benner S, Endo T, Kakeyama M, Tohyama C. Environmental insults in early life and submissiveness later in life in mouse models. Front Neurosci. 2015;9:91. doi:10.3389/fnins.2015.00091.
• Kimura E, Matsuyoshi C, Miyazaki W, et al. Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice. Arch Toxicol. 2016;90(3):691-700. doi:10.1007/s00204-015-1485-x.

2014年

• Benner S, Endo T, Endo N, Kakeyama M, Tohyama C. Early deprivation induces competitive subordinance in C57BL/6 male mice. Physiol Behav. 2014;137:42-52. doi:10.1016/j.physbeh.2014.06.018.
• Kibe R, Kurihara S, Sakai Y, et al. Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Sci Rep. 2014;4:4548. doi:10.1038/srep04548.
• Sugai E, Yoshioka W, Kakeyama M, Ohsako S, Tohyama C. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin modulates dysregulation of the lipid metabolism in mouse offspring fed a high-calorie diet. J Appl Toxicol. 2014;34(3):296-306. doi:10.1002/jat.2881.

2013年

• Kakeyama M, Endo T, Zhang Y, Miyazaki W, Tohyama C. Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins. Arch Toxicol. 2014;88(3):789-798. doi:10.1007/s00204-013-1161-y.
• Doi H, Nishitani S, Fujisawa TX, et al. Prenatal exposure to a polychlorinated biphenyl (PCB) congener influences fixation duration on biological motion at 4-months-old: a preliminary study. PLoS One. 2013;8(3):e59196. doi:10.1371/journal.pone.0059196.
• Oya M, Kitaguchi T, Yanagihara Y, et al. Vesicular nucleotide transporter is involved in ATP storage of secretory lysosomes in astrocytes. Biochem Biophys Res Commun. 2013;438(1):145-151. doi:10.1016/j.bbrc.2013.07.043.

2012年

• Sato M, Kitaguchi T, Numano R, et al. The small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells. Biochem Biophys Res Commun. 2012;420(2):417-421. doi:10.1016/j.bbrc.2012.03.010.

2011年

• Tse D, Takeuchi T, Kakeyama M, et al. Schema-dependent gene activation and memory encoding in neocortex. Science. 2011;333(6044):891-895. doi:10.1126/science.1205274.
• Endo T, Maekawa F, Võikar V, et al. Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage. Behav Brain Res. 2011;221(1):172-181. doi:10.1016/j.bbr.2011.02.037.

2010年

• Koike-Kuroda Y, Kakeyama M, Fujimaki H, Tsukahara S. Use of live imaging analysis for evaluation of cytotoxic chemicals that induce apoptotic cell death. Toxicol In Vitro. 2010;24(7):2012-2020. doi:10.1016/j.tiv.2010.07.022.
• Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C. In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice. Neurotoxicology. 2010;31(4):385-390. doi:10.1016/j.neuro.2010.04.004.

2008年

• Kakeyama M, Sone H, Tohyama C. Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring. J Endocrinol. 2008;197(2):351-358. doi:10.1677/JOE-08-0062.
• Hojo R, Kakeyama M, Kurokawa Y, Aoki Y, Yonemoto J, Tohyama C. Learning behavior in rat offspring after in utero and lactational exposure to either TCDD or PCB126. Environ Health Prev Med. 2008;13(3):169-180. doi:10.1007/s12199-008-0026-0.

2007年

• Tse D, Langston RF, Kakeyama M, et al. Schemas and memory consolidation. Science. 2007;316(5821):76-82. doi:10.1126/science.1135935.
• Win-Shwe TT, Tsukahara S, Ahmed S, et al. Athymic nude mice are insensitive to low-level toluene-induced up-regulation of memory-related gene expressions in the hippocampus. Neurotoxicology. 2007;28(5):957-964. doi:10.1016/j.neuro.2007.08.002.
• Win-Shwe TT, Mitsushima D, Nakajima D, et al. Toluene induces rapid and reversible rise of hippocampal glutamate and taurine neurotransmitter levels in mice. Toxicol Lett. 2007;168(1):75-82. doi:10.1016/j.toxlet.2006.10.017.

2006年

• Tin-Tin-Win-Shwe, Yamamoto S, Ahmed S, Kakeyama M, Kobayashi T, Fujimaki H. Brain cytokine and chemokine mRNA expression in mice induced by intranasal instillation with ultrafine carbon black. Toxicol Lett.2006;163(2):153-160. doi:10.1016/j.toxlet.2005.10.006.
• Nakajima D, Tin-Tin-Win-Shwe, Kakeyama M, Fujimaki H, Goto S. Determination of toluene in brain of freely moving mice using solid-phase microextraction technique. Neurotoxicology. 2006;27(4):615-618. doi:10.1016/j.neuro.2005.12.006.
• Tsukahara S, Kakeyama M, Toyofuku Y. Sex differences in the level of Bcl-2 family proteins and caspase-3 activation in the sexually dimorphic nuclei of the preoptic area in postnatal rats. J Neurobiol. 2006;66(13):1411-1419. doi:10.1002/neu.20276.

2005年

• Ikeda M, Mitsui T, Setani K, et al. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation. Toxicol Appl Pharmacol. 2005;205(1):98-105. doi:10.1016/j.taap.2004.09.010.
• Shwe TT, Yamamoto S, Kakeyama M, Kobayashi T, Fujimaki H. Effect of intratracheal instillation of ultrafine carbon black on proinflammatory cytokine and chemokine release and mRNA expression in lung and lymph nodes of mice. Toxicol Appl Pharmacol. 2005;209(1):51-61. doi:10.1016/j.taap.2005.03.014

2004年

• Fujimaki H, Kurokawa Y, Kakeyama M, et al. Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice. Neuroimmunomodulation. 2004;11(6):373-375. doi:10.1159/000080147.
• Tsukahara S, Inami K, Maekawa F, et al. Postnatal apoptosis, development, and sex difference in the lateral septum of rats.J Comp Neurol. 2004;475(2):177-187. doi:10.1002/cne.20184.

2003年

• Kakeyama M, Sone H, Miyabara Y, Tohyama C. Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activity-dependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood. Neurotoxicology. 2003;24(2):207-217. doi:10.1016/S0161-813X(02)00214-0.

2002年

• Kakeyama M, Umino A, Nishikawa T, Yamanouchi K. Decrease of serotonin and metabolite in the forebrain and facilitation of lordosis by dorsal raphe nucleus lesions in male rats. Endocr J. 2002;49(5):573-579. doi:10.1507/endocrj.49.573.
• Kakeyama M, Sone H, Tohyama C. Changes in expression of NMDA receptor subunit mRNA by perinatal exposure to dioxin. Neuroreport. 2001;12(18):4009-4012. doi:10.1097/00001756-200112210-00031.
• Ohsako S, Miyabara Y, Sakaue M, et al. Developmental stage-specific effects of perinatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on reproductive organs of male rat offspring. Toxicol Sci. 2002;66(2):283-292. doi:10.1093/toxsci/66.2.283.

2001年

• Kanamaru H, Kakeyama M, Seki T, Arai Y. Estrogen potentiates N-methyl-D-aspartate receptor subunit R2B mRNA expression during the late prepubertal period in female rats. Neurosci Lett. 2001;300(1):9-12. doi:10.1016/s0304-3940(01)01527-0.

1998年

• Kakeyama M, Yamanouchi K. Lordosis in male rats: effect of dorsal raphe nucleus cuts. Horm Behav. 1997;32(1):60-67. doi:10.1006/hbeh.1997.1409.

1997年

• Kakeyama M, Negishi M, Yamanouchi K. Facilitatory effect of ventral cut of dorsal raphe nucleus on lordosis in female rats. Endocr J. 1997;44(4):589-593. doi:10.1507/endocrj.44.589.

1996年

• Kakeyama M, Yamanouchi K. Inhibitory effect of baclofen on lordosis in female and male rats with dorsal raphe nucleus lesion or septal cut. Neuroendocrinology. 1996;63(3):290-296. doi:10.1159/000126968.

1994年

• Kakeyama M, Yamanouchi K. Two types of lordosis-inhibiting systems in male rats: dorsal raphe nucleus lesions and septal cuts. Physiol Behav. 1994;56(1):189-192. doi:10.1016/0031-9384(94)90278-x.

1993年

• Kakeyama M, Yamanouchi K. Female sexual behaviors in male rats with dorsal raphe nucleus lesions: treatment with p-chlorophenylalanine. Brain Res Bull. 1993;30(5-6):705-709. doi:10.1016/0361-9230(93)90104-j.
• Kondo Y, Koizumi T, Arai Y, Kakeyama M, Yamanouchi K. Functional relationships between mesencephalic central gray and septum in regulating lordosis in female rats: effect of dual lesions. Brain Res Bull. 1993;32(6):635-638. doi:10.1016/0361-9230(93)90166-9.

1992年

• Yamanouchi K, Kakeyama M. Effect of medullary raphe lesions on sexual behavior in male rats with or without treatments of p-chlorophenylalanine. Physiol Behav. 1992;51(3):575-579. doi:10.1016/0031-9384(92)90182-2.
• Kakeyama M, Yamanouchi K. Lordosis in male rats: the facilitatory effect of mesencephalic dorsal raphe nucleus lesion. Physiol Behav. 1992;51(1):181-184. doi:10.1016/0031-9384(92)90221-m.